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ABSTRACT We present multiwavelength observations of supernova (SN) 2017hcc with the Chandra X-ray telescope and the X-ray telescope onboard Swift (Swift-XRT) in X-ray bands, with the Spitzer and the TripleSpec spectrometer in near-infrared (IR) and mid-IR bands and with the Karl G. Jansky Very Large Array (VLA) for radio bands. The X-ray observations cover a period of 29 to 1310 d, with the first X-ray detection on day 727 with the Chandra. The SN was subsequently detected in the VLA radio bands from day 1000 onwards. While the radio data are sparse, synchrotron-self absorption is clearly ruled out as the radio absorption mechanism. The near- and the mid-IR observations showed that late time IR emission dominates the spectral energy distribution. The early properties of SN 2017hcc are consistent with shock breakout into a dense mass-loss region, with $$\dot{M} \sim 0.1$$ M⊙ yr−1 for a decade. At few 100 d, the mass-loss rate declined to ∼0.02 M⊙ yr−1, as determined from the dominant IR luminosity. In addition, radio data also allowed us to calculate a mass-loss rate at around day 1000, which is two orders of magnitude smaller than the mass-loss rate estimates around the bolometric peak. These values indicate that the SN progenitor underwent an enhanced mass-loss event a decade before the explosion. The high ratio of IR to X-ray luminosity is not expected in simple models and is possible evidence for an asymmetric circumstellar region. 

Mycobacterium tuberculosis ( Mtb ) has complex and dynamic interactions with the human host, and subpopulations of Mtb that emerge during infection can influence disease outcomes. This study implicates zinc ion (Zn 2+ ) availability as a likely driver of bacterial phenotypic heterogeneity in vivo . Zn 2+ sequestration is part of “nutritional immunity”, where the immune system limits micronutrients to control pathogen growth, but this defense mechanism seems to be ineffective in controlling Mtb infection. Nonetheless, Zn 2+ -limitation is an environmental cue sensed by Mtb , as calprotectin triggers the zinc uptake regulator (Zur) regulon response in vitro and co-localizes with Zn 2+ -limited Mtb in vivo . Prolonged Zn 2+ limitation leads to numerous physiological changes in vitro , including differential expression of certain antigens, alterations in lipid metabolism and distinct cell surface morphology. Furthermore, Mtb enduring limited Zn 2+ employ defensive measures to fight oxidative stress, by increasing expression of proteins involved in DNA repair and antioxidant activity, including well described virulence factors KatG and AhpC, along with altered utilization of redox cofactors. Here, we propose a model in which prolonged Zn 2+ limitation defines a population of Mtb with anticipatory adaptations against impending immune attack, based on the evidence that Zn 2+ -limited Mtb are more resistant to oxidative stress and exhibit increased survival and induce more severe pulmonary granulomas in mice. Considering that extracellular Mtb may transit through the Zn 2+ -limited caseum before infecting naïve immune cells or upon host-to-host transmission, the resulting phenotypic heterogeneity driven by varied Zn 2+ availability likely plays a key role during early interactions with host cells. 

Abstract In urban areas, anthropogenic drivers of ecosystem structure and function are thought to predominate over larger‐scale biophysical drivers. Residential yards are influenced by individual homeowner preferences and actions, and these factors are hypothesized to converge yard structure across broad scales. We examined soil total C and total δ¹³C, organic C and organic δ¹³C, total N, and δ¹⁵N in residential yards and corresponding reference ecosystems in six cities across the United States that span major climates and ecological biomes (Baltimore, Maryland; Boston, Massachusetts; Los Angeles, California; Miami, Florida; Minneapolis‐St. Paul, Minnesota; and Phoenix, Arizona). Across the cities, we found soil C and N concentrations and soil δ¹⁵N were less variable in residential yards compared to reference sites supporting the hypothesis that soil C, N, and δ¹⁵N converge across these cities. Increases in organic soil C, soil N, and soil δ¹⁵N across urban, suburban, and rural residential yards in several cities supported the hypothesis that soils responded similarly to altered resource inputs across cities, contributing to convergence of soil C and N in yards compared to natural systems. Soil C and N dynamics in residential yards showed evidence of increasing C and N inputs to urban soils or dampened decomposition rates over time that are influenced by climate and/or housing age across the cities. In the warmest cities (Los Angeles, Miami, Phoenix), greater organic soil C and higher soil δ¹³C in yards compared to reference sites reflected the greater proportion of C₄plants in these yards. In the two warm arid cities (Los Angeles, Phoenix), total soil δ¹³C increased and organic soil δ¹³C decreased with increasing home age indicating greater inorganic C in the yards around newer homes. In general, soil organic C and δ¹³C, soil N, and soil δ¹⁵N increased with increasing home age suggesting increased soil C and N cycling rates and associated¹²C and¹⁴N losses over time control yard soil C and N dynamics. This study provides evidence that conversion of native reference ecosystems to residential areas results in convergence of soil C and N at a continental scale. The mechanisms underlying these effects are complex and vary spatially and temporally.